Тhe subject of research is the field of computational fluid dynamics and numerical simulations. Primarily, the emphasis is on the study of blood flow through blood vessels and the problems that arise. The causes that lead to the process of atherosclerosis in the coronary and carotid arteries and the ways in which it develops further are determined using computer numerical simulations. The starting point is real DICOM images obtained from the world’s most famous hospitals. Using modern software solutions, it is possible to reconstruct them, and such 3D models are the entry point for further three-dimensional solving of blood flow problems.