The investigation include gene variants of the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC) particularly single nucleotide polymorphisms (SNPs), -216G>T (rs712829) and -191C>A (rs712830) and 181946C>T. (D994D) (rs2293347). The importance of the EGFR polymorphisms is in their role as potential molecular targets associated with improved clinical outcomes in NSCLC patients.