Dr. Jovana Muškinja

Starting from the fact that chalcones are suitable for various transformations, we synthesized different chalcones and chalcone analogues that have vanillin in their structure. These compounds often represent the core structure of many natural products. They are very good starting substrates for the preparation of novel azaheterocycles. As such, we used them to synthesize a series of pyrazoline and pyrimidine derivatives in high yields. Some of them showed very good antimicrobial activity, while others passed as useful antitumor agents with expressed cytotoxic activity against tested cancer cell lines. Most importantly, all the new compounds had no toxic effect on a non-cancerous cell line (MRC-5). In continuation of our investigation into the synthesis of different biologically active compounds, we decided to include one of the very useful compounds in organometallic chemistry, ferrocene. A series of ferrocenyl chalcones and ferrocenyl chalcone analogues were obtained, and these products were used in various types of reactions in order to synthesize new azaheterocycles (pyrazolines, oxazoles, pyrimidines, and diazepam derivatives).

1. Janković, J. Muškinja, Z. Ratković, Z. Bugarčić, B. Ranković, M. Kosanić, S. Stefanović, Solvent-free synthesis of novel vanillidene derivatives of Meldrum′s acid: biological evaluation, DNA and BSA binding study. RSC Advances, 6 (2016) 39452-39459. https://doi.org/10.1039/C6RA07711K. ISSN 2046-2069 (IF₂₀₁₄ = 3,840; 33/157; област: Chemistry, Multidisciplinary), М21.
2. Burmudžija, Z. Ratković, J. Muškinja, N. Janković, B. Ranković, M. Kosanić, S. Đorđević, Ferrocenyl based pyrazoline derivatives with vanillic core: synthesis and investigation of its biological properties. RSC Advances, 6 (2016) 91420-91430. https://doi.org/10.1039/C6RA18977F. ISSN 2046-2069 (IF₂₀₁₄ = 3,840; 33/157; област: Chemistry, Multidisciplinary), M21.
3. Muškinja, N. Janković, Z. Ratković, G. Bogdanović, Z. Bugarčić, Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines Molecular Diversity, 20 (2016) 591-604. https://doi.org/10.1007/s11030-016-9658-y. ISSN 1381-1991 (IF₂₀₁₅ = 2,080; 68/163; област: Chemistry, Multidisciplinary), М22.
4. J. M. Muškinja, A. Z. Burmudžija, D. D. Baskić, S. L. Popović, D. V. Todorović, M. M. Zarić, Z. R. Ratković, Synthesis and anticancer activity of chalcone analogues with sulfonyl groups Medicinal Chemistry Research, 28 (2019) 279-291. https://doi.org/10.1007/s00044-018-02283-4. ISSN 1054-2523 (IF₂₀₁₉ = 1,783; 49/61; област: Chemistry, Medicinal), М23.